Dr. Kenneth Gerald Ngwoke

Dr. Kenneth Gerald Ngwoke is a PROFESSOR in PHARMACEUTICAL AND MEDICINAL CHEMISTRY Department, Faculty Of Pharmaceutical Sciences in Nnamdi Azikiwe University

Dr. Kenneth Gerald Ngwoke

Staff Profile

**Natural Products Metabolomics** We investigate different specimen of natural origin including soil fungi, endophytes, micro brown algae and plants for secondary metabolites which are tested for bioactivity against various disease targets. We have specific focus on anti-inflammatory and antimicrobial activities properties of the specimens and their metabolites. It has been established that inflammation is linked to cancer and many disease other diseases. Anti-inflammatory metabolites are potentially useful for cancer management. Our approach is traditional bio-assay guided fractionation using various chromatographic methods including HPLC to fractionate the extracts and isolate the compounds. Spectroscopic methods including NMR and MS are used for structure elucidation and identification of the compounds. Compounds and fractions are tested for anti-inflammatory and antimicrobial properties using various in vivo and in vitro models. We recently concluded tests on 4 plant specimens against COVID-19 wild virus with very interesting outcome. We collaborate with laboratories in Ghana, Germany and the UK **Pharmaceutical Analysis** We carry out the analysis of pharmaceutical products for regulatory compliance using state-of-the-art analytical instruments.This is carried out for research purposes and sometimes on the requests of Pharmaceutical companies

Personal Information

Email:
Phone:
Address:
Pharmaceutical And Medicinal Chemistry, Faculty Of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka.
Faculty/Unit:
FACULTY OF PHARMACEUTICAL SCIENCES
Department/Sub-Unit:
PHARMACEUTICAL AND MEDICINAL CHEMISTRY

Social Profiles

Academic Qualifications

Degrees / Basic Certificates
1Queens University Belfast, UK. (Doctor of Philosophy, July, 2010)
June, 2007 to April, 2010
PhD Natural Product Drug Discovery
2Loughborough University, UK. (Master Degree, December, 2004)
September, 2003 to August, 2004
M.Sc Pharmaceutical Sciences And Medicinal Chemistry
3University Of Nigeria. (Bachelor Degree, July, 2000)
February, 1994 to January, 2000
B.pharm Pharmacy
4Special Science School Abakaliki. (SSCE, June, 1992)
September, 1990 to June, 1992
5Community School Idembia. (FSLC, June, 1986)
March, 1984 to June, 1986
Other / Relevant Certificates
1Kuhne Foundation online training. (Logistics in pandemic) (May, 2021)
May, 2021 to May, 2021
2Massachusetts Institute of Technology(Supply chain Design) (April, 2021)
January, 2021 to April, 2021
3Massachusetts Institute of Technology(Supply chain Technology) (September, 2020)
June, 2020 to August, 2020
4Massachusetts Institute of Technology(Supply chain analytics) (July, 2019)
April, 2019 to June, 2019
5Massachusetts Institute of Technology(Supply Chain Dynamics) (April, 2019)
December, 2018 to April, 2019
6Massachusetts Institute of Technology (October, 2018)
June, 2018 to September, 2018

Relevant/Working Experience

1Special Assistant to The Vice Chancellor(ICT), Nnamdi Azikiwe University, Awka
June, 2019 to Present
2Reader, Nnamdi Azikiwe University, Awka
October, 2018 to Present
3Senior lecturer, Nnamdi Azikiwe University, Awka
October, 2015 to September, 2018
4Coordinator, Forensic Sciences, Nnamdi Azikiwe University, Awka
October, 2014 to May, 2019
5Lecturer 1, Nnamdi Azikiwe University, Awka
October, 2011 to September, 2015
6Head of department, Pharmaceutical and Medicinal Chemistry, Nnamdi Azikiwe University, Awka
October, 2011 to September, 2014
7Special research Scholar, Institute For Global Food Security, Queen University, Belfast
June, 2010 to November, 2010

Creative Output

Book Chapters
1Odimegwu DC, Ngwoke KG, Ejikeugwu C, Esimone CO 2019. (2019, July) Lichen Secondary Metabolites As Possible Antiviral Agents. In Lichen Secondary Metabolites: Bioactive Properties And Pharmaceutical Potentials
2Ngwoke Kenneth Gerald. (2018, March) New pedagogies for effective teaching and learning. In Pharmacists’ council of Nigeria mandatory continuing professional development, Module XIII pp134-164
3Ngwoke Kenneth Gerald. (2015, March) Logistics and supply chain management of medicines and other health commodities. In Pharmacists’ council of Nigeria mandatory continuing professional development, Module XII pp123-131
4Ngwoke. Kenneth Gerald. (2015, July) World Health Organization and medicines regulation. In foreign pharmacy graduate orientation progamme. Pp 241-248
5Ngwoke Kenneth Gerald. (2014, March) Overview of pharmacovigilance: WHO document and FIP position. In Pharmacists’ council of Nigeria mandatory continuing professional development, Module XII pp127-136,
6Ngwoke Kenneth Gerald. (2013, March) Food Safety. In Pharmacists’ council of Nigeria mandatory continuing professional development, Module X pp228-245
7Ngwoke KG, Odimegwu D, Esimone CO. (2011, March) Antimicrobial Natural Product. In Science Against Microbial Pathogens: Communicating Current Research And Technological Advances
Journal Articles
1Vivian O. Okeke, Nkeoma N. Okoye, Kenneth G. Ngwoke, Festus B. Chiedu Okoye. (2021, September), "Antimicrobial Screening And HPLC-DAD-MS Characterization Of The Flavonoid–Rich Fractions Of The Methanol Leaf-Extract Of Lawsonia Inermis Linn", Unknown Journal or Publisher
2Chukwubuikem C. Okolo, Nancy A. Mbachu, Ogechi O. Anyanwu, Kenneth G. Ngwoke and Festus B.C. Okoye. (2021, July), "Screening For Anti-inflammatory Activity Of Extract And Fractions Of Morinda Lucida Stem Bark And Detection Of Bioactive Secondary Metabolite", Unknown Journal or Publisher
3Chigozie C. Ezeagha, Daniel L. Ajaghaku, Eze E. Ajaegbu, Kenneth G. Ngwoke, Patience O. Osadebe, Festus B.C. Okoye. (2021, May), "2021 Molucidine And Desmethylmolucidine As Immunostimulatory Lead Compounds Of Morinda Lucida (Rubiaceae)", Unknown Journal or Publisher
4Kenneth G. Ngwoke, Dina H. El-Kashef, Georgios Daletos, Elena Ancheeva, Zhen Liu Festus B. C. Okoye, Charles O Esimone &Peter Proksch. (2020, January), "R-Hexitronic Acid, A New Tetronic Acid Derivative Isolated From A Soil Fungus FG9RK", Unknown Journal or Publisher
55. Erhirhie EO, Emeghebo CN, Ilodigwe EE, Ajaghaku DL, Umeokoli BO Peter Eze PM, Ngwoke KG, Okoye FBC. (2019, June), "Dryopteris Filix-mas (L.) Schott Ethanolic Leaf Extract And Fractions Exhibited Profound Anti-inflammatory Activity Journal Of Phytomedicine", Unknown Journal or Publisher
6Ngwoke KG, Nwalusiuka T, Ekwealor C, Nwankwo V, Obi-okafor U, Izundu C, Okoye FBC, Esimone CO, Proksch P, Situ C. (2019, March), "Antibacterial, Anti-inflammatory And Peroxidase-mediated Cyclooxygenase-1 Inhibitory Properties Of Fusarium Solani Extract", Unknown Journal or Publisher
76. Ngwoke KG Orame N, Chris-Nwaije A, Ezeigwe A, Atansi C, Anwuchaepe A, Okoye F, Proksch P. (2018, August), "The Anti-inflammatory Property Of Mitracarpus Villosus (Sw.) DC. Extract Is Responsible For Its Use In The Treatment Of Ring Worm Infection", Unknown Journal or Publisher
87. Nwachukwu CU, Ngwoke KG, Eze PM, Eboka CJ, Okoye FBC. (2018, March), "Secondary Metabolites From Curvularia Sp, An Endophytic Fungus Isolated From The Leaves Of Picralima Nitida Durand And Hook (Apocynaceae", Unknown Journal or Publisher
9Anyanwu OO, Ngwoke KG, Okoye FBC. (2018, May), "Bioactive Constituents Responsible For The Anti-inflammatory Actions Of Jatropha Curcas", Unknown Journal or Publisher
10Ngwoke KG, Ezenkwu C, Ajaghaku D, Proksch P. (2018, March), "Staphylococcus Aureus, Bacillus Subtilis And Escherichia Coli Induced Copious Production Of Antibiotics In An Overnight Co-culture With Three Soil Fungi", Unknown Journal or Publisher
1110. Uduma EO, Uwaezuoke JO, Ezeifeany C, Ngwoke KG, Chukwu K, Umeyor V, Esimone CO. (2017, April), "Preservative Efficacy Of The Combination Of Essential Oils Of Cymbopogon Citratus (DC.) Stapf (Poaceae) And Citrus Sinensis (l.) Osbeck (Rutaceae) In A Cream Formulation", Unknown Journal or Publisher
12Ngwoke KG, Nwoye OV, Eze PM, Nworu CS, Okoye FBC, Proksch P. (2017, September), "In Vitro Cytotoxic Properties Of Cladosporium Cladosporioides Extract Against Epithelial Ovarian Cancer Cells A2780 And Mouse Lymphoma Cells L5178Y", Unknown Journal or Publisher
13Ngwoke KG, Ezenkwu C, Ajaghaku D, Proksch P. (2017, June), "Vitexin With Its Derivatives Is Responsible For The Cholinomimetic Properties Of Penianthus Longifolius Extract Which Stimulates Muscarinic Receptors", Unknown Journal or Publisher
14Ngwoke KG, Orame N, Liu S, Okoye FBC, Daletos G, Proksch P. (2017, January), "New Benzophenone Glycoside From The Leaves Of Mitracarpus Villosus", Unknown Journal or Publisher
15Okpongete CE, Okoye NN, Ajaghaku DL, Ngwoke KG, Nworu CS, Okoye FBC. (2016, November), "Ellagic Acid Derivative And Other Compounds From Alchornea Cordifolia Root Bark Exhibited Strong Antioxidant And Antimicrobial Activities", Unknown Journal or Publisher
16Okoye FBC, Ngwoke KG, Debbab A, Osadebe PO, Proksch P. (2016, April), "Olamannoside D And E: Further Kaempferol Triglycosides From Olax Mannii Leaves", Unknown Journal or Publisher
17Ngwoke Kenneth, Eze Peter, Esimone Charles. (2015, January), "Antimicrobial Activity Of Methanol Extract Of Fecal Droppings Of Common House Lizard/gecko (Hemidactylus Frenatus)", Unknown Journal or Publisher
18Maduagwu Ifunanya Juliet, Onyegbule Ahamefule Felix and Ngwoke Kenneth Gerald. (2015, January), "Validation Of Reported HPLC Method For The Simultaneous Determination Of Artemether And Lumefantrine In Low Income Laboratory", Unknown Journal or Publisher
19Enemor EC, Akagha TN, Ngwoke KG, Gugu TH et al. (2015, March), "Phytochemical Analysis And Antimicrobial Activity Of Ethanolic Stem Extracts Of Cnestis Ferruginea On Multidrug Resistant Bacteria Isolated From Raw Retail Meat Sold In Awka, Nigeria", Unknown Journal or Publisher
20Ngwoke KG, Uzoabata T, Ezemokwe I, Esimone, CO. (2015, April), "Levels Of Lead And Arsenic In Groundwater And Blood Of Residents Of Agulu, Nigeria", Unknown Journal or Publisher
21Ngwoke KG, Agu M, Eze P et al.,. (2015, May), "Determination Of Caffeine In Different Brands Of Tea And Coffee Marketed In South Eastern Nigeria", Unknown Journal or Publisher
22Ngwoke KG, Anusi IA, Eze PM, Okezie UM et al. (2015, March), "Phytochemical And Antioxidant Properties Of Stem Bark Extracts Of Anthocleista Nobilis", Unknown Journal or Publisher
23Ngwoke KG, Ikeanyi AU, Eze PM, Ezemokwe IC, Abba CC and Ugwu MC. (2015, March), "Phytochemical And Antioxidant Properties Of Extracts Of Xylopia Aethiopica Fruits", Unknown Journal or Publisher
2424. Ngwoke, K G; Elliott, C; Situ, C.et al. (2014, February), "In Vitro Activity Of Of Diterpenoids Isolated From Aframomum Melegueta Against E. Coli, L. Monocytogenes And Staphylococcus Aureu", Unknown Journal or Publisher
25Ngwoke KG, Iloh Henry, Esimone Charles. (2014, April), "Determination Of Trace Level Fatty Acids And Esters As A Quality Index Of Liquor Produced By Distillation Of Raffia Palm Wine By Local Distillers In Southern Nigeria Using GC-MS", Unknown Journal or Publisher
26Chukwuma G; Okoye L; Ngwoke KG, Esimone CO. (2013, March), "The Potency Of Yellow Fever Vaccines Sold In Open Markets In Eastern Nigeria", Unknown Journal or Publisher
2727. Chukwuma G; Okoye L; Ngwoke KG, Esimone CO. (2013, January), "Spectrophotometric Determination Of Ampicillin And Cloxacillin In Pure And Fixed Dosage Forms Through Charge Transfer Complexation", Unknown Journal or Publisher
28P.A. Akah, S.V. Nwafor, C.O. Okoli, K.G. Ngwoke. (2001, March), ". Purgative Activities Of Aqueous Leaf Extract Of Perianthus Longifolius", Unknown Journal or Publisher
Conference Papers
16. Joseph Black, R.Lavery, K. Ngwoke, A. Mousley, N.J. Marks, A.G. Maule, C.Elliott and C.Situ. (2009, May), "Screening of natural African plant extracts for anthelmintic effects in helminths, British Society for Parasitology Annual Spring Meeting, 5-8 April 2009, Edinburgh University, UK",

Academic Leadership Qualities

Supervisions
1"Chemical And Pharmacological Characterization Of The Leaf Extract And Compounds Isolated From The Leaves Of Mitracarpus Villosus" (March, 2015 to June, 2017). Completed Doctorate project by Orame Stellamaris Njideka M.Sc/2014/65D6003F
2"Anti-inflammatory And Analgesic Principles Of Stem Bark Extract Of Anthocleista Nobilis (G.DON)" (March, 2015 to June, 2017). Completed Masters project by Akwagbulam Chiamaka G. 201465D6002P
3"Phytochemical Studies And Anti-inflammatory Screening Of The Twig Extract Of Jatropha Curcas" (January, 2014 to March, 2017). Completed Masters project by Anyanwu, Ogechi Ozioma M.Sc./2012/676003F
Grants
1Awardee: "Tetfund Book development Grant on Plagiarism" (July, 2019). Completed sponsored grant by TETFund
2Awardee: "Diversity Travel Grant Award" (February, 2019 to August, 2019). Completed sponsored grant by Carl Storm Award
3Awardee: "Conference attendance. grant" (October, 2018). Completed sponsored grant by TETFund
4Awardee: "• TETFund Institution-based award" (September, 2017 to August, 2019). Completed sponsored grant by TETFund
5Awardee: "Post-doctoral fellowship" (December, 2015 to June, 2016). Completed sponsored grant by TWAS-DFG
6Awardee: "Travel Grant" (October, 2013 to October, 2013). Completed sponsored grant by Association of Commonwealth Universities
7Awardee: "Leadership Award" (November, 2010 to January, 2011). Completed sponsored grant by Higginson foundation
8Awardee: "Special post doctoral research grant" (June, 2010 to November, 2010). Completed sponsored grant by Queen's University Belfast
9Awardee: "PhD Studentship" (June, 2007 to April, 2010). Completed sponsored grant by Department of Education and Learning, UK
10Awardee: "Overseas Postgraduate scholarship" (April, 2003 to August, 2004). Completed sponsored grant by Ebonyi State Government
11Collaborator: "TETFund Journal publishing Grant for Journal of current Biomedical Research" (June, 2021). Ongoing sponsored grant by TETFund
12Collaborator: "TETFund COVID-19 Special Research Intervention" (June, 2020). Ongoing sponsored grant by TETFund
Editorships
1Editor, "Journal of Current Biomedical research" (September, 2021)
Reviewerships
1Reviewer, "Antibacterial Agent and Chemotherapy" (August, 2015)
Examinerships
1Chief Examiner, "Pharmacist Council of Nigeria foreign trained certification, Pharmaceutical Chemistry" (April, 2021 to May, 2021). Completed External Exam
Contributions to the University/Society
1Member, "Central ICT Committee, UNIZIK" (August, 2021)
2Chairman, "Faculty of Pharmaceutical Sciences Misconduct Committee" (October, 2018 to May, 2019)
3Member, "Unizik delegation to China" (November, 2017 to November, 2017)
4LOC Chairman, "Local Organising committee, first international Forensic Science & Criminal Science Conference" (July, 2017)
5Member, "Senate Committee on Laboratory Facilities" (October, 2016 to March, 2019)
6Chairman, "PCN professional Accreditation Committtee" (October, 2016 to May, 2017)
7Member, "UNIZIK Convocation Committee" (January, 2016 to December, 2021)
8Member, "ICT Statutory committee, UNIZIK" (April, 2015 to December, 2021)
9LOC Chairman, "Organising committee, HPLC Workshop" (March, 2015)
10Member, "Examination misconduct committee" (October, 2014 to September, 2018)
11LOC Chairman, "Organised supply chain workshop for Pharmacists in Anambra. state in collaboration with USAID" (July, 2014)
12LOC Chairman, "Local Organising committee, first. Annual Forensic Science & Criminal Science Symposium" (July, 2014)
13Member, "Association. of Commonwealth Universities centenary. conference" (October, 2013)
14Member, "NUC Accreditation. committee" (November, 2012)
15UNIZIK representative, "National Biopharmaceutics Harmonisation Committee" (October, 2012)
16Member, "24 National Supply Chain curriculum development committee for Pharmacy schools" (October, 2012 to November, 2012)

Membership of Professional/Relevant Bodies

1Full Member, "National Association of Pharmacists in Academia" (member since 2012), https://napanational.org/